离子通道是一类重要的跨膜蛋白，参与许多重要的生理过程。离子通道功能异常，与疾病的发生息息相关。本课题组围绕疾病相关的离子通道，围绕癫痫、疼痛以及焦虑抑郁等疾病相关靶点，建立了较完备的离子通道筛选平台资源体系，在研究中不断丰富离子通道靶点细胞株的亚型种类和相应的功能筛选评价体系，开展药物筛选和创新药物研究。 本课题组围绕与神经系统疾病相关的离子通道，主要开展以下工作：
1. 以离子通道为靶点的新颖调节剂的发现；
2. 开发靶向癫痫、疼痛以及焦虑抑郁等神经系统疾病的创新药物；
3. 探索和挖掘小分子化合物的新颖作用机制，为疾病治疗寻找新的思路。

1. Jun Zhou #, Jiameng Liu #, Yuchen Jin, Qianyu Wang, Haibo Yu*, Jing-Xiang Wu*. Substrate recognition and allosteric inhibition of human betaine/GABA transporter 1. Nat Commun. 2026 May 19.doi: 10.1038/s41467-026-72924-5.
2. Kexin Yu , Min Li , Yuchen Jin , Miao Zhao , Zeliang Wang , Haibo Yu*, Analgesic effect of cinobufagin is mediated by human-selective P2X7R antagonism governed by distinct extracellular domains. Neuropharmacology. 2026 Mar 1:285:110788. doi: 10.1016/j.neuropharm.2025.110788.
3. Meizhen Tian#, Jun Wu#, Leqi Fan, Jie Zhou, Xiaoyu Wang, Jinping Hu*, Haibo Yu*, Bailing Xu*. Discovery of Novel Isoindolin-1-one Derivatives as GABAA Receptors Positive Allosteric Modulators with Antiepileptic Efficacy. J Med Chem. 2025 Aug 28； 68（16）：17538-17564. doi: 10.1021/acs.jmedchem.5c01161. SCI IF 6.8.
4. Miao Zhao, Yuchen Jin, Jun Wu, Jimei Liu, Min Li, Jungui Dai* and Haibo Yu *.Grifolic acid, a FFAR4 agonist, identified as a dual antagonist of voltage-gated sodium and Cav2.2 channels with potent antinociceptive effects. Br J Pharmacol. 2025 Dec; 182(23): 5826-5846. doi: 10.1111/bph.70165.
5. Min Li , Yuchen Jin, Jun Wu, Miao Zhao, Kexin Yu, Haibo Yu*. Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity. Br J Pharmacol . 2024 Nov;181(21):4311-4327. doi: 10.1111/bph.16496.
6. Miao Zhao,Jun Wu, Yuchen Jin, Min Li, Kexin Yu, Haibo Yu*. Schisandrin B from Schisandra chinensis alleviated pain via glycine receptors, Nav1.7 channels and Cav2.2 channels. J Ethnopharmacol.. 2024 May 23:326:117996.
7. Jun Wu, Miao Zhao, Yu-Chen Jin, Min Li, Ke-Xin Yu, Hai-Bo Yu*. Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models. Acta Pharmacol Sin. 2024 Mar;45(3):465-479.
8. Congyu Ma#, Ning Sheng#, Jun Wu#, Lulu Wang, Jiandong Jiang, Haibo Yu*, Jinlan Zhang*. Active components of Dengzhan Shengmai ameliorate cognitive impairment by facilitating hippocampal long-term potentiation via the NMDA receptor-mediated Ca2+/CaMKII pathway. Journal of Pharmaceutical Analysis. J Pharm Anal. 2024 Mar;14(3):435-438.
9. Jimei Liu#, Zhenfei Wang#, Jun Wu#, Yaotian Han, Fei Ye, Tiantai Zhang, Haibo Yu*, Zhengshun Wen*, Jungui Dai*. Structural diversification of phenylspirodrimane lactams by employing a biosynthetic intermediate. Chinese Chemical Letters, 2023, 34(12): 108363. https://doi.org/10.1016/j.cclet.2023.108363.
10. Keliang Chen# , Tao Wang# , Yong Li# , Jun Wu# , Cheng-Xiao Zhao , Sheng Liu , Fengrun Sun , Yehong Fang , Jiahuan Hu , Jinping Hu , Chong-Jing Zhang* , Haibo Yu* , Chao Ma* , Shi-Shan Yu*. Rhodojaponin VI indirectly targets Cav2.2 channels via N-ethylmaleimide-sensitive fusion protein to alleviate neuropathic pain. Acta Pharm Sin B. 2023 Mar;13(3):1326-1336.
11. Shaohua Li , Yuchen Jin , Min Li , Haibo Yu*.NAN-190, a 5-HT1A antagonist, alleviates inflammatory pain by targeting Nav1.7 sodium channels. Life Sci . 2023 Apr 15;319:121520.
12. Jianan Song# , Mengyuan Jiang# , Yuchen Jin# , Hongrui Li , Yanhong Li , Yumei Liu , Haibo Yu* , Xiangzhong Huang*. Phytol from Faeces Bombycis alleviated migraine pain by inhibiting Nav1.7 sodium channels. J Ethnopharmacol. 2023 Apr 24;306:116161.
13. Jun Wu#, Zhipeng Hou#, Yan Wang, Liping Chen, Chengxi Lian, Qingfei Meng, Chaoying Zhang, Xiufen Li, Longjiang Huang*, Haibo Yu*,Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABAA1 and GABAA4 receptors with potent antiepileptic activity, Bioorganic Chemistry, Volume 119, 2022, 105565, ISSN 0045-2068.
14. Min Li, Haibo Yu *. Identification of WP1066, an inhibitor of JAK2 and STAT3, as a Kv1.3 potassium channel blocker. Bri J Pharmacol . 2021, 178(13):2617-2631.
15. 宋佳男，刘玉梅*，于海波*。神经病理性疼痛的治疗和药物发现现状。药学学报 （Acta Pharmaceutica Sinica） 2021, 56(3): 679 −688。
16. 刘颖，孔令飞*，于海波*。癫痫的治疗和药物发现现状。药学学报 （Acta Pharmaceutica Sinica） 2021, 56(4): 924 −938。